ANTI-PROLIFERATIVE PROPERTY OF PORCUPINE BEZOAR EXTRACT ON MELANOMA (A375). The IC50 result for A375 was found to be 10.1 µg/mL ± 0.17. Retrieved from https://www.thestar.com.my/opinion/online-exclusive/behind-the-cage/2015/06/12/not-a-miracle-cure/, Duffin CJ (2013) Porcupine stones. Tan, C.S., Ng, C.H., Loh, Y.C. The main focus of this review paper is on the porcupine bezoar which can be found in Malaysia. However, its potential as an anticancer agent against human cancers is still poorly studied and understood. Porcupine Bezoar, Klang. MUHAMMAD FARID JOHAN, Porcupine dates are also known as porcupine bezoar, a phytobezoar that is formed from the partly digested plant materials or herbs in the stomach of Himalayan porcupine (Hystrix brachyura) [8,10]. However, its toxicity profile has never been thoroughly ascertained to confirm its safe nature as an efficacious traditional medicine in the treatment of cancer as well as other ailments. CAS  A porcupine’s diet is wide, varied, and a little hard to digest. One of the traditional folk medicine in the Malaysia is using porcupine bezoar. 2. PDF | Porcupine bezoar (PB) has been previously reported to possess various medicinal properties. A bezoar is a mass found trapped in the gastrointestinal system, though it can occur in other locations. It was reported as universal medicine in ancient time. UMMU AFIFAH FADZIR, The selling price of the porcupine bezoar in Malaysia market is around RM300–RM1000 for 500 mg. Porcupine bezoar is undigested concretions of organic or inorganic which calcified and can be found in gastrointestinal tract of porcupine (Malayan hystrix) [7]. Medicinal value of porcupine date and porcupine bezoar Based on the ancient medical books, porcupine belly, meat and glitch have medical value and are able to treat various diseases. The researchers examined e-commerce sites in Indonesia, Malaysia and Singapore for four months in 2019, where they found active for-sale listings for 443 individual bezoars and a large variety of … Porcupine bezoar Apoptosis Cell cycle arrest Anti-angiogenesis Anti-metastasis ABSTRACT Porcupine bezoar (PB) is a calcified undigested material generally found in porcupine’s(Hystrix brachyura) gastrointestinal tract. Tax calculation will be finalised during checkout. PB aqueous extract showed 11.68 μg/mL ± 0.67 TPC value while TFC was not detected confirming the absence of flavonoids in PB aqueous extract. JOURNAL OF BIOMEDICAL AND CLINICAL SCIENCES, 1 (Special Issue). A porcupine’s diet is wide, varied, and a little hard to digest. Azir Salleh, Alfi Khatib, The anti-inflammatory. Porcupine bezoar (PB) has been previously reported to possess various medicinal properties. The chemical profile and the medicinal properties of the bezoar is still unknown. Shaida Fariza Sulaiman, The bezoars found can be either round or elongated with peel like an Hence, in this study, porcupine bezoar (PB) aqueous extract was evaluated for … CAS  Acta med Hist Adriat 12(1):77–98, Brown V (2015) Not a miracle cure. Retrieved from http://www.iucnredlist.org/details/10749/0, Mori E, Sforzi A (2013) Structure of phytobezoars found in the stomach of a crested porcupine, Hystrix cristata L., 1758. - 128.199.74.47. Alaina Yuhanis Firus Khan, PubMed Central  However, its potential as an anticancer agent against human cancers is still poorly studied and understood. Volume 20. Hence, in this study, porcupine bezoar (PB) aqueous extract was evaluated for … The bezoar itself is a medical illness (gastrolith) for porcupines and needs to be surgically removed for the porcupine to survive. Hence, the present study was performed to study PB aqueous extracts (PBAE) in vivo toxicity effects using the zebrafish embryo model. In … In: Akhtar MS, Swamy MK (eds) Anticancer plants: natural products and biotechnological implements. Alaina Yuhainis Firus Khan, PB aqueous extract showed significant anti-proliferation pattern at 24, 48 and 72 hours exposures. Contact Mr.Syaiful +6281389891852 , +601116377848 Porcupine Bezoar Medicinal Values According to Chinese medicine records, in tradition, Porcupine Bezoar had been used as medicine by hill tribes in Southern China and South-East Asia. RIDHWAN ABDUL WAHAB, Interestingly, the scientific proofs of the usage of bezoar were limited. Folia Zool 62(3):232–234, Article  Porcupine bezoar (PB) has been previously reported to possess various medicinal properties. SUHANA MAMAT. Porcupine Bezoar stone is a type of globular stone-like mass occasionally Produced in a porcupine’s internal body. However, limited scientific study has been carried out to verify these traditional claims. Porcupine Bezoar is believed to have medicinal value is very high to the extent that it is called the king of herbs. It is herbivore. Google Scholar, Yew PN, Lee WL, Lim YY (2017) Antioxidant and intracellular reactive oxygen species/reactive nitrogen species scavenging activities of three porcupine bezoars from Hystrix brachyura. Habibah Hassan, Suppliyer porcupine stone / porcupine bezoar. As the 3 (2019): Special Issue: Research Towards Sustainable Development Goals, ANTIBACTERIAL EVALUATION OF Curcuma longa, Punica granatum AND Terminalia catappa EXTRACTS, Hystrix brachyura BEZOAR: AN IN VIVO TOXICITY EVALUATION USING EMBRYO ZEBRAFISH (DANIO RERIO) MODEL. Porcupine bezoar (PB) has been previously reported to possess various medicinal properties. Later I found out that bezoar is a mass of food, usually from consuming grass and herbs, found trapped in an animal’s stomach system and is historically used in Chinese traditional medicine. Tara Jalal, Ridhwan Abdul Wahab. A traditional folk medicine in Malaysia: porcupine bezoar. Porcupine Bezoar is a type of stone-like organic substance found in a porcupine’s body. A study published recently in the journal Global Ecology and Conservation tracked, for the first time, the online trade in old-world porcupines (those from the family Hystricidae in Asia and Africa). E-ISSN 2550-147X Old Chinese medical text had recorded the used of Porcupine Bezoar. Immediate online access to all issues from 2019. Initially PB was infused in water for 18 h to get PB aqueous extract which was preliminary tested for total phenolic content (TPC), total flavonoid content (TFC), DPPH activity in order to confirm the presence of bioactive agents as antioxidants in PB. Firus Khan, Al'aina Yuhainis and Jalal, Tara Kamal and Abdull Rasad, Mohammad Syaiful Bahari and Hashim, Ridzwan and Abdul Wahab, Ridhwan (2016) Porcupine bezoar exhibit as anti-cancer activities on human breast adenocarcinoma cells (MCF-7). The selling price of the porcupine bezoar in Malaysia market is around RM300–RM1000 for 500 mg. Hence, in this study, porcupine bezoar (PB) aqueous extract was evaluated for its potential as a safe anticancer agent. Porcupine bezoar (PB) is used as folk medicine for various medical conditions including cancer treatment in Malaysia. Springer, Singapore, pp 19–39, School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800, Minden, Pulau Pinang, Malaysia, Chu Shan Tan, Chiew Hoong Ng, Yean Chun Loh & Mun Fei Yam, You can also search for this author in It is a mass of ingested wild medicinal herbs and plant parts stored inside the porcupine’s internal digestive or system. The bezoar is traditionally used in South East Asia and Europe for the treatment of cancer, poisoning, dengue, typhoid, etc. Orient Pharm Exp Med 19, 131–136 (2019). The IUCN Red List of Threatened Species. Ng Chiew Hoong participated in the design of the study and performed the statistical analysis. Retrieved from https://www.thestar.com.my/news/nation/2015/08/05/medicine-shops-claim-wildlife-products-a-cureall/#Zv1MlFF3CiX0VwqB.99, Wang DQH, Carey MC (2014) Therapeutic uses of animal biles in traditional Chinese medicine: an Ethnopharmacological, biophysical chemical and medicinal review. This bezoar has been a myth to the locals. In this study, porcupine bezoar is highlighted as potential anticancer agents. Nanyang Siang Pau. Porcupine Bezoar Extract (PBE) has been previously described to possess diverse medicinal properties. A porcupine’s diet is wide, varied, and a little hard to digest. PubMed Google Scholar. Habibah Hassan, Oriental Pharmacy and Experimental Medicine Porcupine bezoar (PB) is used in traditional medicine for various medical conditions. IC50 for DPPH was found to be 0.79 μg/mL ± 0.07. One of the traditional folk medicine in the Malaysia is using porcupine bezoar. Porcupine bezoars (PBs) are masses of undigested calcareous concretions formed within the gastrointestinal tract. © 2020 Springer Nature Switzerland AG. In summary, no, there there is no clinical evidence that Porcupine Bezoar cures cancer or other serious medical illness. However, its potential as an anticancer agent against human cancers is still poorly studied and understood. This bezoar has been a myth to the locals. There are undocumented claims that PBs have antioxidant activity and can treat cancers. It has a coat of sharp spines that defend them from predators. Qamar Uddin Ahmed, Journal metrics 89 days Submission to first decision 200 days Submission to acceptance 16,094 (2019) Downloads. 1 No. PubMed Central  Faizah Abdullah Asuhaimi, Ridhwan Abdul Wahab. A case report [ 43 ] has explained that porcupines which had bezoars suffered clinical signs of weight loss, diarrhea, and depression. Arch Pathol Lab Med 104:159–161, CAS  Genuine Porcupine bezoar is a medically potent and rare animal gall stone that is commonly found in the stomach region of a porcupine. PubMed  It is a molecular biology technique in order to create pores through a cell wall membrane, boost the permeability of the cell membrane, and support chemicals, drugs or DNA to be imported into Hela cells. This manuscript described has not been published before; not under consideration for publication anywhere else; and has been approved by all co-authors. known as porcupine bezoar, a phytobezoar that is formed from the partly digested plant materials or herbs in the stomach of Himalayan porc( Hystrix brachyura )[8, World J Gastroenterol 20(29):9952–9970, Article  Alfi Khatib, Samsul Draman, https://doi.org/10.1007/s13596-019-00370-4, DOI: https://doi.org/10.1007/s13596-019-00370-4, Over 10 million scientific documents at your fingertips, Not logged in Faizah Abdullah Asuhaimi, PubMed  Latest articles. In order to cure bulging diseases, residue in the porcupine can be made into powder and consume with warm wine. Porcupine bezoar was found in the gastrointestinal tract of porcupine and made up of indigestible plant matters. 3 No. Google Scholar, Khan FAY, Nasir MMH, Jalal T, Razali S, Hassan H, Asuhaimi FA, Wahab RA (2017) In vitro evaluation of porcupine bezoar extracts as anticancer agent on A549—a preliminary study. Retrieved from http://www.orientaldaily.com.my/s/74980, Liu XH (2016) The mystery of porcupine bezoar (箭猪枣之迷思). Part of Springer Nature. Pharm Hist (Lond) 43(1):13–22, Endangered animals of the world (2006) Animal info—Malaysia. Their meat is considered a delicacy in countries such as Thailand, Vietnam, and Malaysia. Pharmacogn Res 9(4):366–371, Article  A traditional folk medicine in Malaysia: porcupine bezoar Authors (first, second and last of 4) Chu Shan Tan; Chiew Hoong Ng; Mun Fei Yam; Content type: Review; Published: 28 March 2019; Pages: 131 - 136 FIRUS KHAN, A. Y., ABDULLAH ASUHAIMI, F., JALAL, T., NATTO, H. A., ROHEEM, F. O., AHMED, Q. U., JOHAN, M. F., HASHIM, R., & ABDUL WAHAB, R. (2017). Ibrahim Abuga, Tara Jalal, Google Scholar, Wong LP, AbuBakar S (2013) Health beliefs and practices related to dengue fever: a focus group study. The manuscript was designed and written by Tan Chu Shan. Learn more about Institutional subscriptions, Bao SH (2014) 重镇化痰可治瘟病-箭猪枣非治百病. A Bezoar is a mass trapped in the stomach comprising some indigestible substance ingested by the human or animal. Malaysia Oriental Daily Newspapar. Google Scholar, Yew PN, Goh BH, Lim YY, Lee WL (2018) Gastrointestinal bezoar stones: current knowledge and future perspective on the potential of plant-derived phytobezoar in cancer treatment. While TFC was not detected confirming the absence of flavonoids in PB aqueous extract 11.68... Cancer, poisoning, dengue, typhoid, etc performed the statistical analysis Nippun Sharmin, Alfi Khatib, Abdul... 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