EC Number 203-743-0. The substance has a more sour flavor than citric acid, another common food additive. check_circle Expert Answer. VAT) Qty; FUMARIC ACID (2,3-D2, 98%) DLM-1539-5: 5 G: 98%: … 2006 Dec;5(12):993-6. Recall from Section 1.10B that there is restricted rotation around carbon–carbon double bonds. This information should not be interpreted without the help of a healthcare provider. Its structure is shown in figure 1 (EMBL-EBI, 2017). No hazardous material acc. This application file is based on limited review of Foodchem International Corporation. the solubility rate also increases with smaller particle size. Delivery form. Maleic acid, being a cis-isomer is capable of forming intra-hydrogen bond after losing H + ion, making the conjugate base much stable than the trans form (fumaric acid) because both the oxygen atoms have strong interaction with the remaining H-atom. As intermediate: in pesticides manufacturing. FEMA Number 2488 . [10], Fumarsäure wird auch in Kosmetikartikeln eingesetzt. K. Lohbeck, H. Haferkorn, W. Fuhrmann, N. Fedke: https://de.wikipedia.org/w/index.php?title=Fumarsäure&oldid=207225004, Wikipedia:Vom Gesetzgeber eingestufter Gefahrstoff, „Creative Commons Attribution/Share Alike“, im Nukleotidstoffwechsel bei der Darstellung von. Post navigation ← Entropy Calculation for Ideal Gas Elements General Physical Properties : Atomic Size | Melting point | Boiling point → The conjugate anion formed from the first dissociation is stabilized by the neighboring acidic group for maleic acid, the negative charge is de-intensified. 1–4.Plenum Press: New York, 1976. Fumaric Acid 110-17-8 , Find Complete Details about Fumaric Acid 110-17-8,Fumaric Acid,Fumaric Acid,110-17-8 from Food Additives Supplier or Manufacturer-Shandong Haoyao New Materials Co., Ltd. Nucleic Acids Res. Sie bildet bei Raumtemperatur weiße, fast geruchlose, brennbare Kristalle. Fumaric acid is used in small amounts in the preparation of food, i.e. QTY : Add to my cart . Application Analytes: Fumaric Acid Maleic Acid Methylmalonic Acid. ... Methylmalonic acid, Fumaric acid, Maleic acid . Nat Rev Drug Discov. The reason for this large difference is that when one proton is removed from the cis isomer (maleic acid) a strong intramolecular hydrogen bond is formed with the nearby remaining carboxyl group. [4] Die Verbindung löst sich nur wenig in Wasser. An effective tool for balancing the pH in food and beverages, fumaric acid controls the impact and intensity of sourness and flavor as well as having an anti-microbial and bactericidal effect. It is a precursor to L-malate in the Krebs tricarboxylic acid (TCA) cycle. Definitions of the acid dissociation constant and pKa are given below the figures, together with the definition of some classes of organic acids. 110-17-8 Fumaric acid (Fumarate, 2-Butenedioic acid, Trans-Butenedioic acid) is an intermediate in the citric acid cycle used by cells to produce energy in the form of adenosine triphosphate (ATP) from food; also a product of the urea cycle. [3] Die zweiprotonige Säure hat einen pKs1 von 3,0 und einen pKs2 von 4,5. CAS Nr. Fumarsäure wird in Medizin- und Futtermittelprodukten sowie bei der Herstellung von . organic acids – sorted by formula Fumaric acid has been used in food and beverage products for almost a century and is most commonly relied on to improve quality and reduce costs of many food, beverage, and animal feed products. Seven carboxylic acids are separated based on their polarity and pKa values. CAS No. It has a fruit-like taste and has been used as a food additive. Die isomere cis-Form heißt Maleinsäure. Source : Google images (In the figure, Maleic Acid is forming Intra-hydrogen bond while Fumaric Acid is forming Inter-hydrogen bond). a quantity of 0.317 kg of can replace 0.453 kg of citric acid. Fumaric Acid is an acidulant that is a nonhygroscopic, strong acid of poor solubility. fumaric acid ,Butenedioic acid , Allomaleic acid , Boletic acid , Donitic acid , Lichenic acid. Viele – insbesondere aminogruppenhaltige – pharmazeutisch wirksame Substanzen werden als Salze der Fumarsäure verabreicht. FUMARIC ACID is a carboxylic acid. 25 kg bag. Based on given acidity constants (pK a values) the pH of organic acids for 1, 10, and 100 mmol/L are calculated.The results are listed in the following tables (valid for standard conditions 25°C, 1 atm):. Explain why each of these differences occurs. Application Analytes: Fumaric Acid Hydroxybenzoic Acid Malic Acid Mandelic Acid Methylmalonic Acid Organic Acids Succinic Acid Tartaric Acid. 25 kg bag. Fumarsäure hat unter Normaldruck keinen Schmelzpunkt, sondern sublimiert ab etwa 200 °C. Nat Rev Drug Discov. Bei 15,5 °C lösen sich in 100 g Wasser nur 0,428 g Fumarsäure, bei 100 °C steigt die Löslichkeit auf 9,97 g pro 100 g Wasser. The absence of an interaction does not necessarily mean no interactions exist. Maleic acid, the cis isomer (I), has a melting point of 130°C and a boiling point of 160°C; fumaric acid, the trans isomer (II), has a melting point of 286°C and a boiling point of 290°C. Maleic acid, being a cis-isomer is capable of forming intra-hydrogen bond after losing H + ion, making the conjugate base much stable than the trans form (fumaric acid) because both the oxygen atoms have strong interaction with the remaining H-atom. He Fumaric acid , Also called transbutenodioic acid, is an organic compound of the formula HOOCCH = CHCOOH. There is additional data available for commercial users including Adverse Effects, Contraindications, and Blackbox Warnings. Seven carboxylic acids are separated based on their polarity and pKa values. Weight Average: 116.0722 Monoisotopic: 116.010958616 Chemical Formula C 4 H 4 O 4 Synonyms (2E)-2-butenedioic acid (E)-2-butenedioic acid… FUMARIC ACID FINE - Bulk density Not Established - Specific gravity 1.635 - Viscosity NA - Water solubility 0.5% at 20°C - Solubility (non aqueous) Methyl alcohol: completely miscible - Partition coefficient In OCTANOL/ WATER (log value): Log Kow: -0.2 to -1.8 - Dissociation constant pKa: 3.13, 4.76 and 6.4 at 25° - Evaporation rate NA. In der Schweineaufzucht nutzt man Fumarsäure als Futterzusatz für Ferkel, um colibedingten Infektionen vorzubeugen, indem damit der pH-Wert im Darm ausreichend niedrig gehalten wird. Fumaric acid and maleic acid are the simplest unsaturated carboxylic diacids. Die zweiprotonige Säure hat einen pKs1von 3,0 und einen pKs2 von 4,5. Formula. In the table below, pK a1 and pK a2 for water solutions at 25°C are given together with boiling and melting point, density and molecular weight, as well as number of carbon, hydrogen and oxygen atoms in each molecule. These acids experience two-step dissociation in aqueous solutions.They have the same structural formula but different spatial configurations. [11], Dieser Artikel behandelt ein Gesundheitsthema. Fumaric Acid is widely used as intermediate in Agriculture/Animal Feed. Fumaric acid is a dicarboxylic acid. 5 years ago. They are the isomers of each other. 110-17-8. Die Verbindung löst sich nur wenig in Wasser. In the treatment of psoriasis, doses of several hundred mg are common. it dissolves slowly in cold water, but if mixed with dioctyl sodium sulfosuccinate its solubility improves. Among the side-effects are leucopenia and lymphopenia. Based on given acidity constants (pK a values) the pH of organic acids for 1, 10, and 100 mmol/L are calculated.The results are listed in the following tables (valid for standard conditions 25°C, 1 atm):. Registration dossier . Changes in ionization states of acids and stationary phase can be used to control elution order of organic and inorganic acids. Its chemical formula is HO 2 CCH=CHCO 2 H. Maleic acid is the cis-isomer of butenedioic acid, whereas fumaric acid is the trans-isomer.It is mainly used as a precursor to fumaric acid, and relative to its parent maleic anhydride, maleic acid has few applications. Fumaric Acid. Other identifiers . Step 1. EC Inventory, C&L Inventory, Registration dossier, Pre-Registration process, Other, CAD - Chemical Agents Directive, Art. 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